Application of Protein Language Models to low-N engineering of binder to Metalloproteinase (MP) family of enzymes
Methods & Key Findings :
Metalloproteinases (MPs), a family of zinc-dependent endopeptidases, include matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinases (ADAMs). These enzymes are tightly associated with several diseases when not regulated by their inhibitors and activators, making them attractive targets for developing novel protein-based therapeutics . In this work , we explored application of deep learning models in screening binders to MPs.
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40 UIS Student-Athletes Named Brother James Gaffney Distinguished Scholars
Forty student-athletes from UIS have been named Brother James Gaffney Distinguished Scholars for the 2024-25 academic year. The award, presented by the Great Lakes Valley Conference (GLVC), recognizes student-athletes who completed the academic year with a 4.0 GPA. This marks the third award announcement of GLVC Academic Awards Week, and the UIS honorees are part of a record 684 student-athletes recognized across the conference.
